Girls’ education intervention is an important strategy to achieve gender equality and Universal Basic Education, improve maternal and child health and achieve overall development in Nigeria. Despite multi-sectoral efforts to achieve gender equality in education, Nigeria is still experiencing wide regional and gender disparity. This study reviewed existing empirical literature and critically synthesize factors inhibiting girls’ education in Northern Nigeria. A comprehensive search was conducted to identify empirical studies which dealt with factors inhibiting girls’ education in Northern Nigeria. Studies were identified using a reference period from year 2010 to 2020 based primarily on the variety of bibliographic databases. Additional search was conducted through Google browser to identify non-academic and non-peer reviewed literature related to the study. Systematic Review (SR) of 21 studies were conducted. The SR analysis identified similarity in design but difference in scope, setting, sample and findings. No study investigated all the identified inhibiting factors to girls’ education in Northern Nigeria. Virtually all the studies reported socio-economic factor (poverty) as an inhibitor to girls’ education in Northern Nigeria followed by cultural factor and early marriage/teenage pregnancy. There is need to therefore consider the identified inhibiting factors when designing interventions and developing policies on girls education. Keywords: Girls’ education, inhibiting factors, systematic review, Northern Nigeria.